Short guide:
- Click the Apple icon in the top left corner of the screen, then select System Preferences.
- Click the Accessibility icon, then select Pointer Control from the let-hand column.
- Click the Alternative Control Methods tab.
- Tick the checkbox next to Enable alternative pointer actions, then click Options….
- Click the + (Plus) button to assign a new pointer action.
- Select Facial Expression, then click Next.
- Select an expression from the Facial Expression drop down menu.
- Select an Action to assign it to the Facial Expression you picked. Click Done. You can repeat the same steps to assign other expressions to other useful actions
Before and after
This section takes you step-by-step through assigning pointer actions to facial expressions in macOS, complete with pictures of the screen to help.
Launch System Preferences
1. Click the Apple icon 
in the top left corner of the screen, then System Preferences.
Find the Pointer Control options
2. Click the Accessibility icon to launch the Accessibility settings, then select Pointer Control from the list on the left.
Click Alternative Control Methods
3. Click the Alternative Control Methods tab on the right.
Open the Pointer Actions
4. Tick the checkbox next to Enable alternative pointer actions, and click Options….
Set-up a new pointer action
5. Click the + (Plus) button to assign a new pointer action.
Select Facial Expression
6. Select Facial Expression from the menu, then click Next.
Choose an expression
7. Now select an expression from the Facial Expression menu. This will be the expression you'll use to activate the action.
Choose an action
8. Now select an action from the Action drop down menu. This will be the action you will activate every time you use that expression. Click Done to assign the facial expression. You can repeat the same steps to assign a facial expression to other useful actions, such as a right click or a drag-and-drop.
Note: If this does not work it could be because your computer settings are managed by someone else (an IT department or administrator for example). If this is the case, you will need to contact them to access these settings or for further help.
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