Windows logo key + start typing – this will begin searching your computer for files, documents and programs based on what you are typing.
Windows logo key   + ‘U’ – Open ‘Ease of Access Centre’
Windows logo key + plus (+) or minus (-) – Zoom in or out using Magnifer
Windows logo key   + Esc – Exit Magnifier
Windows logo key + Enter – Open Narrator
Windows logo key + Ctrl + O - Open on-screen keyboard
For a full list of shortcuts see Microsoft Support:
https://support.microsoft.com/en-gb/help/12445/windows-keyboard-shortcuts